Article
Mutations/deletions of the WT1 gene, loss of heterozygosity on chromosome arms 11p and 11q, chromosome ploidy and histology in Wilms' tumors in Japan.
International journal of cancer - 1 Nov 2001
Nakadate H, Yokomori K, Watanabe N, Tsuchiya T, Namiki T, Kobayshi H, Suita S, Tsunematsu Y, Horikoshi Y, Hatae Y, Endo M, Komada Y, Eguchi H, Toyoda Y, Kikuta A, Kobayashi R, Kaneko Y
Abstract excerpt
Incidence rates of Wilms' tumor (WT) markedly differ in East Asian and Caucasian children. In the present study, we examined WT1 deletions/mutations and loss of heterozygosity (LOH) on 11p and 11q in a large number of WTs and compared our findings with those from 4 series of Caucasian WTs. Incidence rates of the subtle WT1 mutation in 3 of the 5 series of sporadic and unilateral WTs including ours were 4.3-6.2%...
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