Article
The genomic organization and expression of the WT1 gene.
Genomics - 1 Apr 1992
Gessler M, König A, Bruns G A
Abstract excerpt
The Wilms tumor gene WT1, a proposed tumor suppressor gene, has been identified based on its location within a homozygous deletion found in tumor tissue. The gene encodes a putative transcription factor containing a Cys/His zinc finger domain. The critical homozygous deletions, however, are rarely seen, suggesting that in many cases the gene may be inactivated by more subtle alterations. To facilitate the search...
Topics
- Amino Acid Sequence
- Base Sequence
- Chromosome Deletion
- Chromosome Mapping
- DNA, Neoplasm
- Exons
- Genes, Wilms Tumor
- Humans
- Introns
- Molecular Sequence Data
- Mutation
- RNA Splicing