Convergent evolution of 11p allelic loss in multifocal Wilms tumors arising in WT1 mutation carriers.

doi:10.1002/pbc.27301

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Article

Convergent evolution of 11p allelic loss in multifocal Wilms tumors arising in WT1 mutation carriers.

Pediatric blood & cancer - 1 Nov 2018

Valind Anders, Wessman Sandra, Pal Niklas, Karlsson Jenny, Jonson Tord, Sandstedt Bengt, Gisselsson David

Abstract excerpt

Wilms tumors in patients with constitutional WT1 mutations are examples of Knudson's tumor suppressor paradigm, with somatic inactivation of the second allele occurring through 11p loss of heterozygosity. The time point of this second hit has remained unknown. We analyzed seven Wilms tumors from two patients with constitutional WT1 mutations by whole exome sequencing and genomic array. All tumors exhibited wild...

Topics

Chromosomes, Human, Pair 11
Genes, Wilms Tumor
Heterozygote
Humans
Infant
Kidney Neoplasms
Loss of Heterozygosity
Male
Mutation
Wilms Tumor

Source

Open in PubMed

Identifiers

PMID: 29968962
DOI: 10.1002/pbc.27301

Genes

CTNNB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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