Article
Kinase-deficient Pak1 mutants inhibit Ras transformation of Rat-1 fibroblasts.
Molecular and cellular biology - 1 Aug 1997
Tang Y, Chen Z, Ambrose D, Liu J, Gibbs J B, Chernoff J, Field J
Abstract excerpt
Among the mechanisms by which the Ras oncogene induces cellular transformation, Ras activates the mitogen-activated protein kinase (MAPK or ERK) cascade and a related cascade leading to activation of Jun kinase (JNK or SAPK). JNK is additionally regulated by the Ras-related G proteins Rac and Cdc...
Topics
- Animals
- COS Cells
- Calcium-Calmodulin-Dependent Protein Kinases
- Cell Line
- Cell Transformation, Neoplastic
- Fibroblasts
- GTP Phosphohydrolases
- GTP-Binding Proteins
- Genes, ras
- JNK Mitogen-Activated Protein Kinases
- Mitogen-Activated Protein Kinase 3
- Mitogen-Activated Protein Kinases
- Mutation
- Oncogene Proteins v-raf