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Article

Kinase-deficient Pak1 mutants inhibit Ras transformation of Rat-1 fibroblasts.

Molecular and cellular biology - 1 Aug 1997

Tang Y, Chen Z, Ambrose D, Liu J, Gibbs J B, Chernoff J, Field J

Abstract excerpt

Among the mechanisms by which the Ras oncogene induces cellular transformation, Ras activates the mitogen-activated protein kinase (MAPK or ERK) cascade and a related cascade leading to activation of Jun kinase (JNK or SAPK). JNK is additionally regulated by the Ras-related G proteins Rac and Cdc42. Ras also regulates the actin cytoskeleton through an incompletely elucidated Rac-dependent mechanism. A candidate...

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Identifiers

PMID: 9234703
DOI: 10.1128/MCB.17.8.4454
PMCID: PMC232299

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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