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Article

Two types of RAS mutants that dominantly interfere with activators of RAS.

Molecular and cellular biology - 1 Jun 1994

Jung V, Wei W, Ballester R, Camonis J, Mi S, Van Aelst L, Wigler M, Broek D

Abstract excerpt

In the fission yeast Schizosaccharomyces pombe, ras1 regulates both sexual development (conjugation and sporulation) and cellular morphology. Two types of dominant interfering mutants were isolated in a genetic screen for ras1 mutants that blocked sexual development. The first type of mutation, at Ser-22, analogous to the H-rasAsn-17 mutant (L. A. Feig and G. M. Cooper, Mol. Cell. Biol. 8:3235-3243, 1988),...

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Identifiers

PMID: 8196614
DOI: 10.1128/mcb.14.6.3707-3718.1994
PMCID: PMC358738

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