Article
Mutational analysis of the Drosophila snake protease: an essential role for domains within the proenzyme polypeptide chain.
Genetics - 1 Apr 1994
Smith C, Giordano H, DeLotto R
Abstract excerpt
Two genes involved in the generation of dorsoventral asymmetry in the developing Drosophila melanogaster embryo, snake and easter, encode the zymogen form of serine proteases. Mutant alleles of snake were cloned and sequenced revealing two types of lesions: point mutations which alter the amino acid sequence (snk073 and snkrm4) and point mutations which alter the splicing (snk229 or snk233) of intron 1 of the...
Topics
- Alleles
- Animals
- Base Sequence
- Catalysis
- Drosophila Proteins
- Drosophila melanogaster
- Enzyme Precursors
- Molecular Sequence Data
- Mutagenesis, Site-Directed
- Oligodeoxyribonucleotides
- Peptide Fragments