Article
Three-dimensional models of proteases involved in patterning of the Drosophila Embryo. Crucial role of predicted cation binding sites.
The Journal of biological chemistry - 28 Mar 2003
Rose Thierry, LeMosy Ellen K, Cantwell Angelene M, Banerjee-Roy Dolly, Skeath James B, Di Cera Enrico
Abstract excerpt
Three-dimensional models of the catalytic domains of Nudel (Ndl), Gastrulation Defective (Gd), Snake (Snk), and Easter (Ea), and their complexes with substrate suggest a possible organization of the enzyme cascade controlling the dorsoventral fate of the fruit fly embryo. The models predict that Gd activates Snk, which in turn activates Ea. Gd can be activated either autoproteolytically or by Ndl. The...
Topics
- Animals
- Binding Sites
- Body Patterning
- Catalysis
- Cations
- Drosophila Proteins
- Drosophila melanogaster
- Models, Molecular
- Mutation
- Protein Conformation
- RNA, Messenger
- Serine Endopeptidases
- Substrate Specificity
- Transcription Factors