Article
Functional analysis of saxophone, the Drosophila gene encoding the BMP type I receptor ortholog of human ALK1/ACVRL1 and ACVR1/ALK2.
Genetics - 1 Oct 2009
Twombly Vern, Bangi Erdem, Le Viet, Malnic Bettina, Singer Matthew A, Wharton Kristi A
Abstract excerpt
In metazoans, bone morphogenetic proteins (BMPs) direct a myriad of developmental and adult homeostatic events through their heterotetrameric type I and type II receptor complexes. We examined 3 existing and 12 newly generated mutations in the Drosophila type I receptor gene, saxophone (sax), the ortholog of the human Activin Receptor-Like Kinase1 and -2 (ALK1/ACVRL1 and ALK2/ACVR1) genes. Our genetic analyses...
Topics
- Activin Receptors, Type I
- Activin Receptors, Type II
- Alleles
- Amino Acid Substitution
- Animals
- Bone Morphogenetic Protein Receptors, Type I
- Crosses, Genetic
- DNA Transposable Elements
- Drosophila Proteins
- Drosophila melanogaster