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Article

Activation of Snake in a serine protease cascade that defines the dorsoventral axis is atypical and pipe-independent in Drosophila embryos.

FEBS letters - 20 Aug 2010

Steen Pamela W, Tian Sufang, Tully Sarah E, Cravatt Benjamin F, LeMosy Ellen K

Abstract excerpt

During Drosophila embryogenesis, establishment of ventral and lateral cell fates requires spatial regulation of an extracellular serine protease cascade composed of Nudel, Gastrulation Defective (GD), Snake, and Easter. Pipe, a sulfotransferase expressed ventrally during oogenesis, sulfates secreted targets that somehow confer positive spatial input to this cascade. Nudel and GD activation are pipe-independent,...

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Identifiers

PMID: 20638387
DOI: 10.1016/j.febslet.2010.07.020
PMCID: PMC2942767

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Activation of Snake in a serine protease cascade that defines the dorsoventral axis is atypical and pipe-independent in Drosophila embryos.PMID 20638387Read ↗

No requirement for localized Nudel protein expression in Drosophila embryonic axis determination.Semantic proximity Read ↗

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Distinct functional specificities are associated with protein isoforms encoded by the Drosophila dorsal-ventral patterning gene pipe.Semantic proximity Read ↗

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Proteolytic processing of the Drosophila Spätzle protein by easter generates a dimeric NGF-like molecule with ventralising activity.Semantic proximity Read ↗

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