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Article

Split top: a maternal cathepsin B that regulates dorsoventral patterning and morphogenesis.

Development (Cambridge, England) - 15 Mar 2016

Langdon Yvette G, Fuentes Ricardo, Zhang Hong, Abrams Elliott W, Marlow Florence L, Mullins Mary C

Abstract excerpt

The vertebrate embryonic dorsoventral axis is established and patterned by Wnt and bone morphogenetic protein (BMP) signaling pathways, respectively. Whereas Wnt signaling establishes the dorsal side of the embryo and induces the dorsal organizer, a BMP signaling gradient patterns tissues along the dorsoventral axis. Early Wnt signaling is provided maternally, whereas BMP ligand expression in the zebrafish is...

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Identifiers

PMID: 26893345
DOI: 10.1242/dev.128900
PMCID: PMC4813285

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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