Proteolytic processing of the Drosophila Spätzle protein by easter generates a dimeric NGF-like molecule with ventralising activity.

doi:10.1016/s0925-4773(98)00024-0

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Article

Proteolytic processing of the Drosophila Spätzle protein by easter generates a dimeric NGF-like molecule with ventralising activity.

Mechanisms of development - 1 Mar 1998

DeLotto Y, DeLotto R

Abstract excerpt

Biochemical interactions underlying the generation of the ventralising signal during Drosophila embryogenesis were investigated by the expression of recombinant Easter and Spätzle proteins. An active form of Easter protease cleaves the Spätzle protein, generating a carboxyterminal polypeptide fra...

Topics

Amino Acid Sequence
Animals
Cells, Cultured
Dimerization
Disulfides
Drosophila
Drosophila Proteins
Embryo, Nonmammalian
Insect Proteins
Ligands
Models, Molecular
Molecular Sequence Data
Nerve Growth Factors
Peptide Fragments
Phenotype
Protein Structure, Secondary
Recombinant Proteins
Serine Endopeptidases

Source

Open in PubMed

Identifiers

PMID: 9533958
DOI: 10.1016/s0925-4773(98)00024-0

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Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9533958-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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