Article
DNA lesions, inducible DNA repair, and cell division: three key factors in mutagenesis and carcinogenesis.
Environmental health perspectives - 1 Dec 1993
Ames B N, Shigenaga M K, Gold L S
Abstract excerpt
DNA lesions that escape repair have a certain probability of giving rise to mutations when the cell divides. Endogenous DNA damage is high: 10(6) oxidative lesions are present per rat cell. An exogenous mutagen produces an increment in lesions over the background rate of endogenous lesions. The e...
Topics
- Animals
- Cell Division
- Clone Cells
- DNA Damage
- DNA Repair
- Diet
- Female
- Humans
- Male
- Mutagenesis
- Mutation
- Neoplasms