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Article

DNA lesions, inducible DNA repair, and cell division: three key factors in mutagenesis and carcinogenesis.

Environmental health perspectives - 1 Dec 1993

Ames B N, Shigenaga M K, Gold L S

Abstract excerpt

DNA lesions that escape repair have a certain probability of giving rise to mutations when the cell divides. Endogenous DNA damage is high: 10(6) oxidative lesions are present per rat cell. An exogenous mutagen produces an increment in lesions over the background rate of endogenous lesions. The effectiveness of a particular lesion depends on whether it is excised by a DNA repair system and the probability that it...

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Identifiers

PMID: 8013423
DOI: 10.1289/ehp.93101s535
PMCID: PMC1519422

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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