Article
Endogenous genotoxic agents and processes as a basis of spontaneous carcinogenesis.
Mutation research - 1 May 1990
Lutz W K
Abstract excerpt
A list of endogenous DNA-damaging agents and processes is given. Endogenous electrophiles are found with the cosubstrates of physiological transfer reactions (S-adenosylmethionine for methylation, ATP for phosphorylation, NAD+ for ADP-ribosylation, acetyl CoA for acetylation). Aldehyde groups (gl...
Topics
- Animals
- Carcinogens
- DNA
- DNA Damage
- Humans
- Mutagens
- Mutation
- Neoplasms
