Article
Can a non-tumorigenic dose of carcinogen cause two or more errors in a cell?
Cancer letters - 15 Jun 1992
Volpe J P
Abstract excerpt
Cancer is believed to be the result of a multistep process, beginning with a single alteration in a cell's genome. Here the hypothesis that a few cells may receive two or more hits after the application of a non-tumorigenic or higher dose of carcinogen is proposed. Preneoplastic lesions that arise from such doubly-hit cells may be few in number, but may more easily undergo tumor formation and tumor progression....
Topics
- Animals
- Carcinogens
- DNA Damage
- DNA Replication
- Dose-Response Relationship, Drug
- Kinetics
- Mice
- Models, Biological
- Mutation
- Precancerous Conditions