Biomonitoring for genotoxic effects has a low sensitivity in terms of cancer risks associated with lifelong exposures starting in utero.

Abstract excerpt

Cancer risk is probably function of the accumulation of mutations in stem cells. These stem cells divide probably about 10 times less frequently than peripheral cell populations. In the case of exposure during adulthood, the peripheral cell populations dividing at the time of exposure will present an increased mutant frequency that can be detected by a biomonitoring test. Stem cells will have divided only a few...

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