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Article

Oxidants Are a Major Contributor to Aginga

1 Nov 1992

Abstract excerpt

Very high level oxidative damage to DNA occurs during normal metabolism. In each rat cell the steady-state level of this damage is estimated to be about 10(6) oxidative adducts, and about 10(5) new adducts are formed daily. This endogenous DNA damage appears to be a major contributor to aging and to the degenerative diseases associated with aging such as cancer. The oxidative damage rate in mammalian species with...

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Identifiers

PMID: 1482105
DOI: 10.1111/j.1749-6632.1992.tb38652.x

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