Article
Endogenous DNA damage and spontaneous mutagenesis in cultured mammalian cells.
Annali dell'Istituto superiore di sanita - 1 Jan 1994
Aquilina G
Abstract excerpt
This review describes the main molecular mechanisms of endogenous mutagenesis, with reference to the possible sources of the different DNA lesions, the types of mutation originated and the specific defense strategies employed by the cell. The analysis of mutations induced by mutagenic agents that...
Topics
- Alkylation
- Animals
- Cells, Cultured
- Chromosome Aberrations
- DNA Damage
- DNA Repair
- DNA Replication
- DNA Transposable Elements
- DNA-Directed DNA Polymerase
- Deamination
- Gene Amplification
- Mammals
- Mutagenesis
- Mutation
- Nucleic Acids
- Oxygen