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Cell proliferation and carcinogenesis: an approach to screening for potential human carcinogens

28 May 2024

Abstract excerpt

Cancer arises from multiple genetic errors occurring in a single stem cell (clonality). Every time DNA replicates, mistakes occur. Thus, agents can increase the risk of cancer either by directly damaging DNA (DNA-reactive carcinogens) or increasing the number of DNA replications (increased cell proliferation). Increased cell proliferation can be achieved either by direct mitogenesis or cytotoxicity with...

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PMID: 38868530
DOI: 10.3389/fonc.2024.1394584

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