Cell cycle control, DNA repair and initiation of carcinogenesis.

doi:10.1096/fasebj.7.12.8375618

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Article

Cell cycle control, DNA repair and initiation of carcinogenesis.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Sept 1993

Kaufmann W K, Kaufman D G

Abstract excerpt

We hypothesize that degradation of controls that normally act to inhibit cell proliferation is an early step in carcinogenesis. This alteration gives rise to initiated clones that display a selective growth advantage over normal cells when subjected to appropriate growth-promoting influences. In cell culture, such initiated cells also may display a selective growth advantage that lets them proliferate under...

Topics

Animals
Cell Cycle
Cell Division
DNA Repair
Humans
Mutation
Neoplasms

Source

Open in PubMed

Identifiers

PMID: 8375618
DOI: 10.1096/fasebj.7.12.8375618

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