Article
Mutations in the predicted aspartyl tRNA synthetase of Drosophila are lethal and function as dosage-sensitive maternal modifiers of the sex determination gene Sex-lethal.
Molecular & general genetics : MGG - 1 Feb 1999
Stitzinger S M, Pellicena-Palle A, Albrecht E B, Gajewski K M, Beckingham K M, Salz H K
Abstract excerpt
Stable activation of the Drosophila sex determination gene Sex-lethal in the female embryo is a multistep process. Early in embryogenesis Sex-lethal is regulated at the level of transcription, and then later in embryogenesis Sex-lethal regulation switches to an autoregulatory RNA splicing mechanism. Previous studies have shown that successful activation of Sxl requires both maternally and zygotically provided...
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