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Article

The translation initiation factor eIF4E regulates the sex-specific expression of the master switch gene Sxl in Drosophila melanogaster.

PLoS genetics - 1 Jul 2011

Graham Patricia L, Yanowitz Judith L, Penn Jill K M, Deshpande Girish, Schedl Paul

Abstract excerpt

In female fruit flies, Sex-lethal (Sxl) turns off the X chromosome dosage compensation system by a mechanism involving a combination of alternative splicing and translational repression of the male specific lethal-2 (msl-2) mRNA. A genetic screen identified the translation initiation factor eif4e as a gene that acts together with Sxl to repress expression of the Msl-2 protein. However, eif4e is not required for...

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Identifiers

PMID: 21829374
DOI: 10.1371/journal.pgen.1002185
PMCID: PMC3145617

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Source receipt: pubmed, retrieved 7 Sept 2026.

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The translation initiation factor eIF4E regulates the sex-specific expression of the master switch gene Sxl in Drosophila melanogaster.PMID 21829374Read ↗

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