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Article

Soluble tapasin restores MHC class I expression and function in the tapasin-negative cell line .220.

Immunity - 1 Feb 1998

Lehner P J, Surman M J, Cresswell P

Abstract excerpt

Tapasin forms a bridge between TAP (transporters associated with antigen processing) and MHC class I molecules and plays a critical role in class I assembly. In its absence, TAP and class I do not associate, and class I cell surface expression is reduced. We now identify two independent functions...

Topics

ATP Binding Cassette Transporter, Subfamily B, Member 2
ATP Binding Cassette Transporter, Subfamily B, Member 3
ATP-Binding Cassette Transporters
Antigen Presentation
Antiporters
Biological Transport
Endoplasmic Reticulum
HLA-B8 Antigen
Humans
Immunoglobulins
Membrane Transport Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Peptides

Protein Binding

Solubility

T-Lymphocytes, Cytotoxic

Source

Identifiers

PMID: 9492003
DOI: 10.1016/s1074-7613(00)80474-4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9492003-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Soluble tapasin restores MHC class I expression and function in the tapasin-negative cell line .220.PMID 9492003Read ↗

Productive association between MHC class I and tapasin requires the tapasin transmembrane/cytosolic region and the tapasin C-terminal Ig-like domain.Semantic proximity Read ↗

Impaired assembly yet normal trafficking of MHC class I molecules in Tapasin mutant mice.Semantic proximity Read ↗

HLA-B27-restricted antigen presentation in the absence of tapasin reveals polymorphism in mechanisms of HLA class I peptide loading.Semantic proximity Read ↗

Distinct functions of tapasin revealed by polymorphism in MHC class I peptide loading.Semantic proximity Read ↗

Elucidation of the genetic basis of the antigen presentation defects in the mutant cell line .220 reveals polymorphism and alternative splicing of the tapasin gene.Semantic proximity Read ↗

Assembly of tapasin-associated MHC class I in the absence of the transporter associated with antigen processing (TAP).Semantic proximity Read ↗

Impaired immune responses and altered peptide repertoire in tapasin-deficient mice.Semantic proximity Read ↗

Critical role for the tapasin-docking site of TAP2 in the functional integrity of the MHC class I-peptide-loading complex.Semantic proximity Read ↗

The cell biology of major histocompatibility complex class I assembly: towards a molecular understandingSemantic proximity Read ↗

Quantitative and Qualitative Influences of Tapasin on the Class I Peptide RepertoireSemantic proximity Read ↗

The Transporter Associated With Antigen Processing (TAP): Structural Integrity, Expression, Function, and Its Clinical RelevanceSemantic proximity Read ↗

Recruitment of MHC class I molecules by tapasin into the transporter associated with antigen processing-associated complex is essential for optimal peptide loading.Semantic proximity Read ↗

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