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Article

Mutation of the alpha 2 domain disulfide bridge of the class I molecule HLA-A*0201. Effect on maturation and peptide presentation.

Human immunology - 1 Apr 1994

Warburton R J, Matsui M, Rowland-Jones S L, Gammon M C, Katzenstein G E, Wei T, Edidin M, Zweerink H J, McMichael A J, Frelinger J A

Abstract excerpt

A combination of saturation and site-directed mutagenesis was utilized to disrupt the alpha 2 domain disulfide bridge of HLA-A*0201. Mutation of cysteine 101 to a serine (C101S) or of cysteine 164 to alanine (C164A) decreased the rate of maturation of the heavy chain, the total amount of mature heavy chain within the cell, and the level of surface expression. Cells expressing these genes and loaded with a...

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Identifiers

PMID: 8071101
DOI: 10.1016/0198-8859(94)90269-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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