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Article

A mutant human histocompatibility leukocyte antigen DR molecule associated with invariant chain peptides.

The Journal of experimental medicine - 1 Feb 1994

Mellins E, Cameron P, Amaya M, Goodman S, Pious D, Smith L, Arp B

Abstract excerpt

From a human histocompatibility leukocyte antigen (HLA)-DR/DQ hemizygous, B lymphoblastoid progenitor, we isolated a cell line, 10.24.6, with a DR alpha missense mutation (96P-->96S), which results in an N-linked carbohydrate addition at position 94 in the DR alpha 2 domain. Several features of 10.24.6 cells suggest that the mutation disrupts normal intracellular formation of peptide/DR complexes. The mutant...

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Identifiers

PMID: 8294865
DOI: 10.1084/jem.179.2.541
PMCID: PMC2191365

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