Article
Elucidation of the genetic basis of the antigen presentation defects in the mutant cell line .220 reveals polymorphism and alternative splicing of the tapasin gene.
European journal of immunology - 1 Nov 1998
Copeman J, Bangia N, Cross J C, Cresswell P
Abstract excerpt
Antigenic peptides are presented to cytotoxic T lymphocytes by heterodimers of MHC class I molecules and beta2-microglobulin. Peptides are generated in the cytosol and translocated into the endoplasmic reticulum (ER) through the transporter associated with antigen processing (TAP). Optimal bindin...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 2
- ATP-Binding Cassette Transporters
- Alternative Splicing
- Antigen Presentation
- Antiporters
- B-Lymphocytes
- Cell Line
- DNA, Complementary
- Endoplasmic Reticulum
- Exons
- Humans
- Immunoglobulins
- Membrane Transport Proteins
- Mutation