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Article

A mutant v-rel with increased ability to transform B lymphocytes.

Journal of virology - 1 Jan 1995

Romero P, Humphries E H

Abstract excerpt

We observed that two strains of REV-T differ in the ability to transform bursal cells in vitro. REV-TW, with v-rel derived from a well-characterized clone and considered the prototype of the wild type, fails to generate colonies in soft agar. In contrast, REV-S2A3, derived from the S2A3 cell line, readily transforms bursal cells. With PCR, a 1,591-bp fragment containing v-rel from the REV-S2A3 provirus was cloned...

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Identifiers

PMID: 7983722
DOI: 10.1128/JVI.69.1.301-307.1995
PMCID: PMC188576

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Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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A mutant v-rel with increased ability to transform B lymphocytes.PMID 7983722Read ↗

Multiple mutations contribute to the oncogenicity of the retroviral oncoprotein v-Rel.Semantic proximity Read ↗

Transformation by the vRel oncoprotein requires sequences carboxy-terminal to the Rel homology domain.Semantic proximity Read ↗

Differences in kappaB DNA-binding properties of v-Rel and c-Rel are the result of oncogenic mutations in three distinct functional regions of the Rel protein.Semantic proximity Read ↗

Mutational analysis of v-rel, the oncogene of reticuloendotheliosis virus strain T.Semantic proximity Read ↗

Three mutations in v-Rel render it resistant to cleavage by cell-death protease caspase-3.Semantic proximity Read ↗

The N-terminal env-derived amino acids of v-rel are required for full transforming activity.Semantic proximity Read ↗

ERK and JNK activation is essential for oncogenic transformation by v-Rel.Semantic proximity Read ↗

Interaction of the v-Rel oncoprotein with NF-kappaB and IkappaB proteins: heterodimers of a transformation-defective v-Rel mutant and NF-2 are functional in vitro and in vivo.Semantic proximity Read ↗

In vivo evolution of c-rel oncogenic potential.Semantic proximity Read ↗

v-Rel and c-Rel are differentially affected by mutations at a consensus protein kinase recognition sequence.Semantic proximity Read ↗

The v-rel oncogene of avian reticuloendotheliosis virus transforms immature and mature lymphoid cells of the B cell lineage in vitro.Semantic proximity Read ↗

Mutant envelope residues confer a transactivation function onto N-terminal sequences of the v-Rel oncoprotein.Semantic proximity Read ↗

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