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Article

Three mutations in v-Rel render it resistant to cleavage by cell-death protease caspase-3.

Biochimica et biophysica acta - 3 Apr 2001

Barkett M, Dooher J E, Lemonnier L, Simmons L, Scarpati J N, Wang Y, Gilmore T D

Abstract excerpt

The retroviral oncoprotein v-Rel is a transcriptional activator in the Rel/NF-kappa B family. v-Rel causes rapidly fatal lymphomas in young chickens, and transforms and immortalizes chicken lymphoid cells in vitro. Several mutations that have enhanced the oncogenicity of v-Rel have been selected during in vitro and in vivo passage of v-Rel-containing retroviruses. In this report, we show that the C-terminal...

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PMID: 11287119
DOI: 10.1016/s0304-4165(01)00092-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Three mutations in v-Rel render it resistant to cleavage by cell-death protease caspase-3.PMID 11287119Read ↗

Multiple mutations contribute to the oncogenicity of the retroviral oncoprotein v-Rel.Semantic proximity Read ↗

Mutational analysis of v-rel, the oncogene of reticuloendotheliosis virus strain T.Semantic proximity Read ↗

In vivo evolution of c-rel oncogenic potential.Semantic proximity Read ↗

Transformation by the vRel oncoprotein requires sequences carboxy-terminal to the Rel homology domain.Semantic proximity Read ↗

Differences in kappaB DNA-binding properties of v-Rel and c-Rel are the result of oncogenic mutations in three distinct functional regions of the Rel protein.Semantic proximity Read ↗

Mutant envelope residues confer a transactivation function onto N-terminal sequences of the v-Rel oncoprotein.Semantic proximity Read ↗

Malignant transformation by mutant Rel proteins.Semantic proximity Read ↗

Mutations in the v-Rel transactivation domain indicate altered phosphorylation and identify a subset of NF-kappaB-regulated cell death inhibitors important for v-Rel transforming activity.Semantic proximity Read ↗

Discreet mutations from c-Rel to v-Rel alter kappaB DNA recognition, IkappaBalpha binding, and dimerization: implications for v-Rel oncogenicity.Semantic proximity Read ↗

ERK and JNK activation is essential for oncogenic transformation by v-Rel.Semantic proximity Read ↗

The v-rel oncogene of avian reticuloendotheliosis virus transforms immature and mature lymphoid cells of the B cell lineage in vitro.Semantic proximity Read ↗

An optimal range of transcription potency is necessary for efficient cell transformation by c-Rel to ensure optimal nuclear localization and gene-specific activation.Semantic proximity Read ↗

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