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Article

Germ line variable regions that match hypermutated sequences in genes encoding murine anti-hapten antibodies.

Genetics - 1 Nov 1992

David V, Folk N L, Maizels N

Abstract excerpt

We asked whether there are germ line immunoglobulin variable (V) segments that match sites of hypermutation in V regions encoding murine antibodies. Murine germ line DNA was probed with a panel of short deoxyoligonucleotides identical in sequence to segments of hypermutated V regions from hybridomas generated in the BALB/c response to the hapten 2-phenyloxazolone (Ox). Germ line sequences that match mutations in...

Topics

Animals
Base Sequence
DNA Probes
Gene Conversion
Gene Rearrangement, B-Lymphocyte
Genes, Immunoglobulin
Genetic Variation
Immunoglobulin Variable Region
Mice
Mice, Inbred BALB C
Mice, Inbred C57BL

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Mutation

Oxazolone

Sequence Alignment

Source

Open in PubMed Open full text

Identifiers

PMID: 1468632
DOI: 10.1093/genetics/132.3.799
PMCID: PMC1205216

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1468632-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Germ line variable regions that match hypermutated sequences in genes encoding murine anti-hapten antibodies.PMID 1468632Read ↗

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