Mutation and selection during the secondary response to 2-phenyloxazolone.

doi:10.1073/pnas.88.13.5508

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Article

Mutation and selection during the secondary response to 2-phenyloxazolone.

Proceedings of the National Academy of Sciences of the United States of America - 1 Jul 1991

Rada C, Gupta S K, Gherardi E, Milstein C

Abstract excerpt

The most characteristic feature of the mouse antibody response to the hapten 2-phenyloxazolone is the recurrent expression of the light-chain variable region Igk-VO chi 1 gene in its germ-line or mutated configuration. The analysis of somatic mutants of the Igk-VO chi 1 gene reported here indicates that, as found during the primary response, hypermutation is also activated during the secondary response. Somatic...

Topics

Amino Acid Sequence
Animals
Antibody Diversity
Antibody-Producing Cells
B-Lymphocytes
Base Sequence
Genes, Immunoglobulin
Haptens
Immunoglobulin Variable Region
Immunoglobulin kappa-Chains
Immunologic Memory

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Molecular Sequence Data

Mutation

Oligonucleotides

Oxazolone

Polymerase Chain Reaction

Source

Open in PubMed Open full text

Identifiers

PMID: 1905811
DOI: 10.1073/pnas.88.13.5508
PMCID: PMC51906

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1905811-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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