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Article

Mutation and selection during the secondary response to 2-phenyloxazolone.

Proceedings of the National Academy of Sciences of the United States of America - 1 Jul 1991

Rada C, Gupta S K, Gherardi E, Milstein C

Abstract excerpt

The most characteristic feature of the mouse antibody response to the hapten 2-phenyloxazolone is the recurrent expression of the light-chain variable region Igk-VO chi 1 gene in its germ-line or mutated configuration. The analysis of somatic mutants of the Igk-VO chi 1 gene reported here indicates that, as found during the primary response, hypermutation is also activated during the secondary response. Somatic...

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Identifiers

PMID: 1905811
DOI: 10.1073/pnas.88.13.5508
PMCID: PMC51906

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Mutation and selection during the secondary response to 2-phenyloxazolone.PMID 1905811Read ↗

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