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Article

Accumulation of somatic mutants in the B cell compartment after primary immunization with a T cell-dependent antigen.

European journal of immunology - 1 Feb 1992

Weiss U, Zoebelein R, Rajewsky K

Abstract excerpt

The accumulation of somatic mutants in splenic B lymphocytes early after primary immunization with the hapten (4-hydroxy-3-nitro-phenyl)acetyl (NP) coupled to chicken gamma globulin (CG) was determined. Rearranged V186.2 heavy chain genes were amplified by the polymerase chain reaction from genomic DNA and subjected to nucleotide sequence analysis. Somatic antibody mutants become detectable on day 6 after...

Topics

Amino Acid Sequence
Animals
B-Lymphocytes
Base Sequence
Gene Rearrangement, B-Lymphocyte, Heavy Chain
Genes, Immunoglobulin
Immunization
Immunologic Memory
Mice
Mice, Inbred C57BL
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Nitrophenols

Phenylacetates

Polymerase Chain Reaction

Time Factors

Source

Identifiers

PMID: 1537385
DOI: 10.1002/eji.1830220233

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1537385-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Accumulation of somatic mutants in the B cell compartment after primary immunization with a T cell-dependent antigen.PMID 1537385Read ↗

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