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[Cancer genetics of TSC2 gene mutant(Eker) rat model].

Nihon rinsho. Japanese journal of clinical medicine - 1 Jun 2000

Hino O

Abstract excerpt

Cancer is a heritable disorder of somatic cells. Environment and heredity both operate in the origin of human cancer. Hereditary cancers have been important in the understanding of carcinogenesis, and have pointed to the first tumor suppressor genes. Such a hereditary cancer was described in the rat by Reidar Eker in 1954. The Eker rat model of hereditary renal carcinoma is an example of a Mendelian dominantly...

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Source

Identifiers

PMID: 10879050

Genes

TSC2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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[Cancer genetics of TSC2 gene mutant(Eker) rat model].PMID 10879050Read ↗

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The predisposing gene of the Eker rat inherited cancer syndrome is tightly linked to the tuberous sclerosis (TSC2) gene.Semantic proximity Read ↗

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Predisposition to renal carcinoma in the Eker rat is determined by germ-line mutation of the tuberous sclerosis 2 (TSC2) gene.Semantic proximity Read ↗

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