Isolation and characterization of a rat homologue of the human tuberous sclerosis 1 gene (Tsc1) and analysis of its mutations in rat renal carcinomas.

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Article

Isolation and characterization of a rat homologue of the human tuberous sclerosis 1 gene (Tsc1) and analysis of its mutations in rat renal carcinomas.

Cancer research - 15 Feb 1999

Satake N, Kobayashi T, Kobayashi E, Izumi K, Hino O

Abstract excerpt

In the Eker rat, a germ-line mutation in the homologue of the human tuberous sclerosis gene (Tsc2) causes renal cell carcinomas (RCs) with a complete penetrance in all heterozygotes. Tsc2 mutations have also been found in a subset of chemically induced non-Eker rat RCs. Because tuberous sclerosis patients with alteration of either of the two predisposing genes (TSC1 and TSC2) show identical symptoms, the products...

Topics

Adult
Aged
Amino Acid Sequence
Animals
Base Sequence
Chromosome Mapping
Female
Humans
Kidney Neoplasms
Male
Middle Aged
Molecular Sequence Data
Mutation
Proteins
RNA, Messenger
Rats
Rats, Inbred F344
Tuberous Sclerosis Complex 1 Protein

Source

Open in PubMed

Identifiers

PMID: 10029074

Genes

TSC1
TSC2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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