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Article

The Genetic Basis of Kidney Cancer: Why is Tuberous Sclerosis Complex Often Overlooked?

1 Dec 2004

Abstract excerpt

Fifty years ago, the Eker rat was identified as the first animal model of hereditary renal adenoma and carcinoma, with histopathology resembling human renal carcinoma. Ten years ago, a mutation in the TSC2 gene was identified in the Eker rat at Fox Chase Cancer Center by Yeung and Knudson, and in Tokyo by Kobayashi and Hino. The literature contains dozens of reports of renal cell carcinoma (RCC) in tuberous...

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PMID: 15579029
DOI: 10.2174/1566524043359610

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