Article
Targeted disruption of the even-skipped gene, evx1, causes early postimplantation lethality of the mouse conceptus.
Genes & development - 15 Aug 1994
Spyropoulos D D, Capecchi M R
Abstract excerpt
Implantation within the mammalian uterus elicits dramatic changes in the growth, differentiation, and morphogenesis of the conceptus. This process is interrupted in mice carrying a targeted disruption of the murine evx1 gene, a homolog of the Drosophila even-skipped (eve) gene. Upon implantation, presumptive evx1- homozygotes elicit a decidual response, invade the uterine epithelium, and attach to the basement...
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