Article
Loss of the extraembryonic ectoderm in Elf5 mutants leads to defects in embryonic patterning.
Development (Cambridge, England) - 1 May 2005
Donnison Martyn, Beaton Angela, Davey Helen W, Broadhurst Ric, L'Huillier Phil, Pfeffer Peter L
Abstract excerpt
The extraembryonic ectoderm (ExE) is essential for mammalian placental formation and survival of the embryo in utero. We have obtained a mouse model lacking the ExE, by targeted deletion of the transcription factor Elf5. Although Elf5 mutant embryos implant and form an ectoplacental cone, no trophoblast stem (TS) cells can be derived, indicating that the absence of ExE is a result of the lack of TS cell...
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