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Article

Genetic analysis of sorting nexins 1 and 2 reveals a redundant and essential function in mice.

Molecular biology of the cell - 1 Oct 2002

Schwarz Dana Gilbert, Griffin Courtney T, Schneider Elizabeth A, Yee Della, Magnuson Terry

Abstract excerpt

Sorting nexins 1 (Snx1) and 2 (Snx2) are homologues of the yeast gene VPS5 that is required for proper endosome-to-Golgi trafficking. The prevailing thought is that Vps5p is a component of a retrograde trafficking complex called the retromer. Genetic and biochemical evidence suggest mammals may have similar complexes, but their biological role is unknown. Furthermore, if SNX1 and SNX2 belong to such complexes, it...

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Source

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Identifiers

PMID: 12388759
DOI: 10.1091/mbc.e02-03-0145
PMCID: PMC129968

Genes

SNX1
SNX2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Genetic analysis of sorting nexins 1 and 2 reveals a redundant and essential function in mice.PMID 12388759Read ↗

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