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Article

p53 is overexpressed in fifty percent of pre-invasive lesions of head and neck epithelium.

Carcinogenesis - 1 Oct 1994

Sauter E R, Cleveland D, Trock B, Ridge J A, Klein-Szanto A J

Abstract excerpt

To identify the stage in head and neck carcinogenesis at which p53 abnormalities become important, we evaluated 512 squamous epithelial tissue samples (201 pre-invasive and 209 invasive lesions, as well as 102 normal epithelia) in specimens from two institutions. Of 311 patients evaluated, 128 did not have an invasive carcinoma. The frequency of p53 overexpression in the pre-invasive lesions was not influenced by...

Topics

Adult
Aged
Aged, 80 and over
Carcinoma, Squamous Cell
Epithelium
Female
Genes, p53
Half-Life
Head and Neck Neoplasms
Humans
Immunohistochemistry
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Middle Aged

Mutation

Neoplasm Invasiveness

Precancerous Conditions

Tumor Suppressor Protein p53

Source

Identifiers

PMID: 7955065
DOI: 10.1093/carcin/15.10.2269

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7955065-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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