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Article

p53 mutation and protein accumulation during multistage human esophageal carcinogenesis.

Cancer research - 1 Nov 1992

Bennett W P, Hollstein M C, Metcalf R A, Welsh J A, He A, Zhu S M, Kusters I, Resau J H, Trump B F, Lane D P

Abstract excerpt

Preinvasive lesions of squamous cell carcinoma are well defined morphologically and provide a model for multistage carcinogenesis. Since alterations in the p53 tumor suppressor gene occur frequently in invasive esophageal squamous cell carcinoma, we examined a set of preinvasive lesions to investigate the timing of p53 mutation. Surgically resected tissues from nine patients with esophageal squamous cell...

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PMID: 1394236

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