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Article

p53 mutation and protein accumulation during multistage human esophageal carcinogenesis.

Cancer research - 1 Nov 1992

Bennett W P, Hollstein M C, Metcalf R A, Welsh J A, He A, Zhu S M, Kusters I, Resau J H, Trump B F, Lane D P

Abstract excerpt

Preinvasive lesions of squamous cell carcinoma are well defined morphologically and provide a model for multistage carcinogenesis. Since alterations in the p53 tumor suppressor gene occur frequently in invasive esophageal squamous cell carcinoma, we examined a set of preinvasive lesions to investigate the timing of p53 mutation. Surgically resected tissues from nine patients with esophageal squamous cell...

Topics

Base Sequence
Carcinoma in Situ
Carcinoma, Squamous Cell
Codon
Esophageal Neoplasms
Exons
Genes, p53
Humans
Molecular Sequence Data
Mutation
Precancerous Conditions

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Tumor Suppressor Protein p53

Source

Identifiers

PMID: 1394236

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1394236-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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