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Article

Immunohistochemical staining patterns of p53 predict the mutational status of TP53 in oral epithelial dysplasia.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Feb 2022

Sawada Keisuke, Momose Shuji, Kawano Ryutaro, Kohda Masakazu, Irié Tarou, Mishima Kenji, Kaneko Takahiro, Horie Norio, Okazaki Yasushi, Higashi Morihiro, Tamaru Jun-Ichi

Abstract excerpt

Next-generation sequencing of oral squamous cell carcinoma (OSCC) has revealed TP53 as the most frequently mutated gene in OSCC mutually exclusive with human papillomavirus infection. Oral epithelial dysplasia (OED) is defined as a precancerous lesion of OSCC by the current World Health Organization (WHO) classification; therefore, it is assumed that TP53 mutations occur in early precancerous conditions such as...

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Source

Identifiers

PMID: 34404905
DOI: 10.1038/s41379-021-00893-9

Genes

TP53

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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