Article
The changing face of p53 in head and neck cancer.
International journal of oral and maxillofacial surgery - 1 Dec 2007
Partridge M, Costea D E, Huang X
Abstract excerpt
p53 plays a sentinel role in the pathways that prevent development of cancer by inducing apoptosis, DNA repair and cell-cycle arrest in response to different types of cellular stress. The majority of head and neck tumours harbour mutations affecting the p53 gene, and those tumours that seemingly have wild-type p53 protein most probably lack a functional p53 response as a result of mutations affecting other genes...
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