Mutational profiling can identify laryngeal dysplasia at risk of progression to invasive carcinoma.

doi:10.1038/s41598-018-24780-7

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Article

Mutational profiling can identify laryngeal dysplasia at risk of progression to invasive carcinoma.

Scientific reports - 26 Apr 2018

Manterola Lorea, Aguirre Pablo, Larrea Erika, Arestín María, Gaafar Ayman, Elorriaga Kepa, Goicoechea Ibai, Armesto María, Fernández-Mercado Marta, Zabalza Ignacio, López-Duque Juan Carlos, Larruskain Ekhiñe, Sistiaga Jon Alexander, Landa Mikel, Zabala Aitor, Santaolalla Francisco, Municio José Antonio, Ispizua Ángel, García-Pedrero Juana María, Rodrigo Juan Pablo, Lawrie Charles Henderson

Abstract excerpt

Early diagnosis of laryngeal squamous cell carcinoma (LSCC) at the stage of dysplasia could greatly improve the outcome of affected patients. For the first time we compared the mutational landscape of non-progressing dysplasia (NPD; n = 42) with progressing dysplasia (PD; n = 24), along with patient-matched LSCC biopsies; a total of 90 samples. Using targeted next-generation sequencing identified non-synonymous...

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Identifiers

PMID: 29700339
DOI: 10.1038/s41598-018-24780-7
PMCID: PMC5919930

Genes

FGFR3
JAK3
MET

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