Article
Delineating an epigenetic continuum in head and neck cancer.
Cancer letters - 28 Jan 2014
Worsham Maria J, Stephen Josena K, Chen Kang Mei, Havard Shaleta, Shah Veena, Gardner Glendon, Schweitzer Vanessa G
Abstract excerpt
A tissue field of somatic genetic alterations precedes the histopathological phenotypic changes of carcinoma. Genomic changes could be of potential use in the diagnosis and prognosis of pre-invasive squamous head and neck carcinoma (HNSCC) lesions and as markers for cancer risk assessment. Studies of sequential molecular alterations and genetic progression of pre-invasive HNSCC have not been clearly defined....
Topics
- Animals
- Biomarkers, Tumor
- Carcinoma, Squamous Cell
- Cell Transformation, Neoplastic
- DNA Methylation
- Disease Progression
- Epigenesis, Genetic
- Gene Expression Regulation, Neoplastic
- Genetic Predisposition to Disease
- Genetic Testing
- Head and Neck Neoplasms
- Humans
- Papilloma