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Article

Accumulation of nuclear p53 and tumor progression in bladder cancer.

The New England journal of medicine - 10 Nov 1994

Esrig D, Elmajian D, Groshen S, Freeman J A, Stein J P, Chen S C, Nichols P W, Skinner D G, Jones P A, Cote R J

Abstract excerpt

BACKGROUND: We have previously demonstrated a strong association between nuclear accumulation of p53 protein, as determined by immunohistochemical analysis, and mutations in the p53 gene. The purpose of this study was to determine the relation between nuclear accumulation of p53 and tumor progression in transitional-cell carcinoma of the bladder. METHODS: Histologic specimens of transitional-cell carcinoma of the...

Topics

Aged
Aged, 80 and over
Biomarkers, Tumor
Carcinoma, Transitional Cell
Cystectomy
Disease Progression
Female
Humans
Male
Middle Aged
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neoplasm Recurrence, Local

Survival Analysis

Tumor Suppressor Protein p53

Urinary Bladder Neoplasms

Source

Identifiers

PMID: 7935683
DOI: 10.1056/NEJM199411103311903

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7935683-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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