Article
Relationship between p53 gene mutation and protein expression: clinical significance in transitional cell carcinoma of the bladder.
International journal of oncology - 1 Mar 2000
Gao J P, Uchida T, Wang C, Jiang S X, Matsumoto K, Satoh T, Minei S, Soh S, Kameya T, Baba S
Abstract excerpt
Although the mutated p53 gene has been postulated to induce immunohistochemically-detectable p53 protein, reports regarding the relationship between p53 mutation and p53 protein expression have been contradictory. This study investigated the relationship between p53 mutations and p53 expression and their clinical significance for patients with transitional cell carcinoma of the bladder. Eighty-seven transitional...
Topics
- Adult
- Aged
- Aged, 80 and over
- Carcinoma, Transitional Cell
- Female
- Genes, p53
- Humans
- Immunohistochemistry
- Male
- Middle Aged
- Mutation
- Polymorphism, Single-Stranded Conformational
- Prognosis
- Survival Rate