Article
The p53 tumor suppressor gene and nuclear protein: basic science review and relevance in the management of bladder cancer.
The Journal of urology - 1 Apr 2003
Smith Norm D, Rubenstein Jonathan N, Eggener Scott E, Kozlowski James M
Abstract excerpt
PURPOSE: An extensive body of literature regarding p53 has accumulated during the last 2 decades. The cellular mechanisms of p53 are complex yet well-defined, whereas its clinical usefulness in the management of bladder cancer remains controversial. We outline the basic constitutive functions of p53 and summarize its current role in the management of transitional cell carcinoma of the bladder. MATERIALS AND...
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