p53 protein accumulation and gene mutation in the progression of human prostate carcinoma.

doi:10.1093/jnci/85.20.1657

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Article

p53 protein accumulation and gene mutation in the progression of human prostate carcinoma.

Journal of the National Cancer Institute - 20 Oct 1993

Navone N M, Troncoso P, Pisters L L, Goodrow T L, Palmer J L, Nichols W W, von Eschenbach A C, Conti C J

Abstract excerpt

BACKGROUND: Nuclear accumulation of p53 protein has been shown to be strongly associated with missense p53 mutations. Studies of nuclear accumulation of p53 protein in prostate carcinoma cells have to date been confined to material from primary tumors. PURPOSE: We studied the accumulation of p53 protein in specimens obtained from primary and metastatic sites of prostate carcinoma. By examining the accumulation of...

Topics

Adult
Aged
Aged, 80 and over
Base Sequence
Carcinoma
Chi-Square Distribution
Genes, p53
Humans
Logistic Models
Lymphatic Metastasis
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Middle Aged

Molecular Sequence Data

Mutation

Neoplasms, Hormone-Dependent

Polymerase Chain Reaction

Polymorphism, Genetic

Prostatic Hyperplasia

Source

Open in PubMed

Identifiers

PMID: 7692074
DOI: 10.1093/jnci/85.20.1657

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7692074-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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