Nuclear overexpression of p53 protein in transitional cell bladder carcinoma: a marker for disease progression.

doi:10.1093/jnci/85.1.53

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Article

Nuclear overexpression of p53 protein in transitional cell bladder carcinoma: a marker for disease progression.

Journal of the National Cancer Institute - 6 Jan 1993

Sarkis A S, Dalbagni G, Cordon-Cardo C, Zhang Z F, Sheinfeld J, Fair W R, Herr H W, Reuter V E

Abstract excerpt

BACKGROUND: Approximately one third of the patients with superficially infiltrative transitional cell (T1-TNM pathological staging system) bladder carcinoma who are treated with transurethral resection alone have disease progression. Despite precise pathologic staging and grading, clinical outcome in these patients is not predictable. Recent reports reveal that mutations of the p53 tumor suppressor gene (also...

Topics

Adult
Aged
Aged, 80 and over
Analysis of Variance
Biomarkers, Tumor
Carcinoma in Situ
Carcinoma, Transitional Cell
Female
Genes, p53
Humans
Immunoenzyme Techniques

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Middle Aged

Multivariate Analysis

Mutation

Neoplasm Proteins

Neoplasm Staging

Neovascularization, Pathologic

Source

Open in PubMed

Identifiers

PMID: 7677935
DOI: 10.1093/jnci/85.1.53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7677935-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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