Article
Rescue of the HNF4 --> HNF1alpha pathway in hepatoma variant cells containing human chromosome 12.
Genomics - 15 Dec 1998
Bulla G A, Batanian J R, Young H M, Bradley N, Kazi N, Haddad B R
Abstract excerpt
Expression of liver-enriched trans-acting hepatocyte nuclear factors 1alpha (HNF1alpha) and 4 (HNF4) is correlated with the hepatic phenotype in cultured rat hepatoma cells. We have used a hepatoma variant cell line, H11, that specifically lacks the HNF4 --> HNF1alpha pathway as a model to unders...
Topics
- Animals
- Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
- Carcinoma, Hepatocellular
- Cells, Cultured
- Chromosomes, Human, Pair 12
- Chromosomes, Human, Pair 6
- Chromosomes, Human, Pair 7
- DNA-Binding Proteins
- Gene Expression
- Genetic Complementation Test
- Hepatocyte Nuclear Factor 1
- Hepatocyte Nuclear Factor 1-alpha
- Hepatocyte Nuclear Factor 1-beta
- Hepatocyte Nuclear Factor 4
- Humans
- Hybrid Cells
- Nuclear Proteins
- Phenotype