Article
Rescue of the HNF4 --> HNF1alpha pathway in hepatoma variant cells containing human chromosome 12.
Genomics - 15 Dec 1998
Bulla G A, Batanian J R, Young H M, Bradley N, Kazi N, Haddad B R
Abstract excerpt
Expression of liver-enriched trans-acting hepatocyte nuclear factors 1alpha (HNF1alpha) and 4 (HNF4) is correlated with the hepatic phenotype in cultured rat hepatoma cells. We have used a hepatoma variant cell line, H11, that specifically lacks the HNF4 --> HNF1alpha pathway as a model to understand mechanisms controlling hepatic gene expression. We have introduced randomly marked human chromosomes into H11...
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