Article
Regulation of albumin gene expression in hepatoma cells of fetal phenotype: dominant inhibition of HNF1 function and role of ubiquitous transcription factors.
Molecular biology of the cell - 1 Jan 1993
Rollier A, DiPersio C M, Cereghini S, Stevens K, Tronche F, Zaret K, Weiss M C
Abstract excerpt
Two widely used hepatoma cell lines, mouse BW1J and human HepG2, express gene products characteristic of fetal hepatocytes, including serum albumin, whereas reporter genes driven by the albumin promoter are expressed at very low levels compared with highly differentiated hepatoma cells. We have i...
Topics
- Animals
- DNA-Binding Proteins
- Gene Expression Regulation, Neoplastic
- Hepatocyte Nuclear Factor 1
- Hepatocyte Nuclear Factor 1-alpha
- Hepatocyte Nuclear Factor 1-beta
- Humans
- Liver Neoplasms, Experimental
- Mice
- Nuclear Proteins
- Phenotype
- Promoter Regions, Genetic
- Serum Albumin