Article
More potent transcriptional activators or a transdominant inhibitor of the HNF1 homeoprotein family are generated by alternative RNA processing.
The EMBO journal - 1 Nov 1993
Bach I, Yaniv M
Abstract excerpt
We report the isolation of cDNAs from human liver encoding several isoforms of the hepatocyte nuclear factor homeoproteins HNF1 and vHNF1 generated by the differential use of polyadenylation sites and by alternative splicing. In the novel isoforms intron sequences that are excised in the previous...
Topics
- Alternative Splicing
- Amino Acid Sequence
- Animals
- Base Sequence
- DNA-Binding Proteins
- Gene Expression Regulation
- Genes, Homeobox
- Genetic Variation
- Hepatocyte Nuclear Factor 1
- Hepatocyte Nuclear Factor 1-alpha
- Hepatocyte Nuclear Factor 1-beta
- Humans
- Liver
- Models, Genetic
- Molecular Sequence Data
- Multigene Family
- Nuclear Proteins
- Poly A